Eat To Beat MG

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 The following information is presented for educational purposes only. EatToBeatMG.com provides the following information to provide an understanding of the potential applications of cannabidiol. We share and create a discussion about possible alternative ways to improve symptoms, health or things to be cautious with. Your experience and thoughts are welcomed.

 

Overview of Myasthenia Gravis

As we all know, Myasthenia gravis is a chronic autoimmune neuromuscular disease characterized by a breakdown in communication between nerves and muscles, resulting in weakness and rapid fatigue. The muscle weakness associated with myasthenia gravis increases when one is active, but then improves after periods of rest. The degree of muscle weakness varies greatly between individuals.

Myasthenia gravis causes the immune system to produce antibodies that either block or destroy muscles’ receptor sites for the neurotransmitter acetylcholine. With some receptors blocked, the muscles receive fewer signals and subsequently prevent muscles from contracting, resulting in weakness. Sometimes the antibodies, rather than block receptor sites, block the function of a protein called muscle-specific receptor tyrosine kinase, which is involved in creating the nerve-muscular junction.

Due to muscular weakness and fatigue, myasthenia gravis also commonly causes eyelids to droop and can make it difficult to speak, swallow, chew, and make facial expressions. The neck and breathing muscles can also be affected in some cases.

Anticholinesterase medications are often prescribed and effective at inhibiting the enzyme acetylcholinesterase, which is responsible for catalyzes the breakdown of acetylcholine. By inhibiting acetylcholinesterase, the amount of acetylcholine at the neuromuscular junction increases and eventually overcomes the blocked receptors.


Findings: Effects of Cannabis on Myasthenia Gravis

Research suggests that cannabis, like anticholinesterase agents, has the capability of inhibiting acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine. By inhibiting acetylcholinesterase, acetylcholine has more time to interact with its receptor before its breakdown, or turnover, and can therefore overcome the blocked receptor and cause muscle contractions. 

Multiple cannabinoids have demonstrated effective at increasing acetylcholine levels and slowing acetylcholine turnover. One study found that tetrahydrocannabinol (THC), a major cannabinoid found in cannabis, completely inhibited acetylcholinesterase, thereby raising the levels of the neurotransmitter (Eubanks, et al., 2006). Another study showed that three cannabinoids, including THC, cannabidiol (CBD), and cannabinol (CBN), each caused a significant elevation of acetylcholine in the brain and THC and CBN caused a decrease in acetylcholine turnover (Tripathi, Vocci, Brase & Dewey, 1987). Additional studies have demonstrated THC and CBD’s effectiveness at decreasing acetylcholine turnover rate (Revuelta, Moroni, Cheney & Costa, 1978) (Revuelta, et al., 1980).

Cannabinoids’ long understood pharmacological effects are caused by their activation of cannabinoid receptors. However, the cannabinoid’s effects on enzymes and neurotransmitter transporters appear to be due to a mechanism other than their activation of cannabinoid receptors, but the exact method is yet to be fully understood (Oz, et al., 2014). 

States That Have Approved Medical Marijuana for Myasthenia Gravis

Currently, only the state of Illinois has approved medical marijuana specifically for the treatment of myasthenia gravis. However, in Washington D.C., any condition can be approved for medical marijuana as long as a DC-licensed physician recommends the treatment. In addition, a number of other states will consider allowing medical marijuana to be used for the treatment of myasthenia gravis with the recommendation from a physician. These states include: California (any debilitating illness where the medical use of marijuana has been recommended by a physician), Connecticut (other medical conditions may be approved by the Department of Consumer Protection), Massachusetts (other conditions as determined in writing by a qualifying patient’s physician), Nevada (other conditions subject to approval), Oregon (other conditions subject to approval), Rhode Island (other conditions subject to approval), and Washington (any “terminal or debilitating condition”).


Recent Studies on Cannabis’ Effect on Myasthenia Gravis

  • THC shown to completely inhibit acetylcholinesterase, the enzyme responsible for the degradation of acetylcholine.
    A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology. 
    (http://www.ncbi.nlm.nih.gov/pubmed/17140265)
  • Animal trials show THC, CBN and CBD significantly increases acetylcholine in the brain and THC and CBD decreased acetylcholine turnover.
    Effects of cannabinoids on levels of acetylcholine and choline and on turnover rate of acetylcholine in various regions of the mouse brain.
    (http://www.ncbi.nlm.nih.gov/pubmed/3620017)

 

References

Eubanks, L. M., Rogers, C. J., Beuscher, A. E., Koob, G. F., Olson, A. J., Dickerson, T. J., & Janda, K. D. (2006). A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology. Molecular Pharmaceutics, 3(6), 773–777.

Myasthenia gravis. (2013, April 23). Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/myasthenia-gravis/basics/definition/con-20027124.

Myasthenia Gravis Fact Sheet. (2015, July 27). National Institute of Neurological Disorders and Stroke. Retrieved from http://www.ninds.nih.gov/disorders/myasthenia_gravis/detail_myasthenia_gravis.htm.

Oz, M., Al Kury, L., Keun-Hang, S.Y., Mahgoub, M., and Galadari, S. (2014, May 15). Cellular approaches to the interaction between cannabinoid receptor ligands and nicotinic acetylcholine receptors. European Journal of Pharmacology, 731, 100-5.

Revuelta, A.V., Cheney, D.L., Costa, E., Lander, N., and Mechoulam, R. (1980, August 18). Reduction of hippocampal acetylcholine turnover in rats treated with (-)-delta 8-tetrahydrocannabinol and its 1′,2′-dimethyl-heptyl homolog. Brain Research, 195(2), 445-52.

Revuelta, A.V., Moroni, F., Cheney, D.L., and Costa, E. (1978, September). Effect of cannabinoids on the turnover rate of acetylcholine in rat hippocampus, striatum and cortex. Naunyn-Schmiedeberg’s Achives of Pharmacology, 304(2), 107-10.

Tripathi, H.L., Vocci, F.J., Brase, D.A., and Dewey, W.L. (1987). Effects of cannabinoids on levels of acetylcholine and choline and on turnover rate of acetylcholine in various regions of the mouse brain. Alcohol and Drug Research, 7(5-6), 525-32.

 

Article adapted from medicalmarijuanainc.com

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I have written previously on the undeniable benefits of exercise for those living with MG as well as my own personal journey back to health which most defiantly included (and still does to this day), exercise or ‘physical therapy’.  

So after being inspired by my good friend who is on a similar journey of improving his health after not being able to walk, today, I wanted to share a helpful and informative video with all of you. 

 

My dear friends…I want to remind you that when you take the time to focus on improving the various elements of health, your body will respond and your health will improve. Speaking from personal experience, by incorporating physical therapy, upgrading nutrition and working to reduce stress and calm the mind, you can and over time will, improve your strength and overall MG health.

*Always talk to your doctor before starting a physical wellness plan and never exercise if in a crisis. Don’t be afraid to ask your doctor to request physical therapy as part of your treatment plan!

Myasthenia Gravis and Exercise 

Video from the Myasthenia Gravis Foundation of Illinois

 

 

 Have you read:

Exercise for MG: the 9 tips you need to know 

 


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Have you ever thought about visiting an Osteopathic physician since being diagnosed with Myasthenia Gravis?  

 

Medical News Today explains that, “Osteopathy is a form of drug-free non-invasive manual medicine that focuses on total body health by treating and strengthening the musculoskeletal framework, which includes the joints, muscles and spine. Its aim is to positively affect the body’s nervous, circulatory and lymphatic systems. 

This therapy is a unique holistic (whole body) approach to health care. Osteopaths do not simply concentrate on treating the problem area, but use manual techniques to balance all the systems of the body, to provide overall good health and wellbeing.”

 

 

Why Try?

The overall philosophy of treating the body with osteopathic care (complementary to other existing treatments) is what really stands out. So many times we see doctors and physicians who, although may do a terrific job, fail to integrate the important goal of whole body wellness into a plan for treatment. 

 “The philosophy of Osteopathy is what sets it apart from other medical disciplines. The key principles are based on all parts of the body functioning together in an integrated manner. If one part of the body is restricted, then the rest of the body must adapt and compensate for this, eventually leading to inflammation, pain, stiffness and other health conditions. When the body is free of restrictions in movement, Osteopathic treatment assists the body with pain minimization, reduced stress and greater mobility providing the body with the opportunity to heal itself.”

 




 

 

Chronic illness

This is especially important for those living with various chronic illnesses. Naturally, the entire body should be functioning in a friendly manner but when the symptoms of chronic illness shows up, something within the system of our body has very obviously been thrown off.

General improvement in mobility and structural stability of the body are known benefits of osteopathic care. While this course of action may not be beneficial for all chronic conditions, It may play a positive part in the lives of Myasthenia Gravis patients. The possibility for improved overall body function due to improvement of structural stability and general mobility is there. 

In addition, when the body is internally and physically at a resting, pain-free and stress-free state, other systems within body such as the circulatory, nervous and lymphatic systems function more effectively. This is what osteopathic treatment aims to help. 

 

Symptom relief for general wellbeing

While this is not by any means the end all be all of Myasthenia Gravis symptoms, I see great potential for osteopathic care to be a solid complementary treatment while working towards whole body health. It is important that we keep what muscle and strength we do have to push back against the potential for muscle atrophy – which can easily happen as many of us are not as mobile as we once were.

I have experienced the benefit of guided strength training as well as muscle release therapy for pain reduction myself. Both of which improved my mobility and general strength overtime. The key is to work with someone who is aware of the quick weakness and fatigue Myasthenia Gravis can cause. While you must ease into any physical treatment, given time, I feel that physical therapy or Osteopathic treatment has the potential to greatly help those living with Myasthenia Gravis. 

Yes, we may have a few things pushing against us but as long as we’re pushing back, we will always have persistence and determination on our side.

 



*the complementary treatment described above is meant to share a look into another therapy that can be looked into in addition to continuing your normal doctors care but not in place of. As always, make sure you are stable enough, especially with breathing, and talk to your doctor before trying any physical complementary treatment.

 

source: http://www.medicalnewstoday.com/articles/70381.php

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